Article
The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. II. An autosomal genome scan for diabetes-related quantitative-trait loci.
American journal of human genetics - 1 Nov 2000
Watanabe R M, Ghosh S, Langefeld C D, Valle T T, Hauser E R, Magnuson V L, Mohlke K L, Silander K, Ally D S, Chines P, Blaschak-Harvan J, Douglas J A, Duren W L, Epstein M P, Fingerlin T E, Kaleta H S, Lange E M, Li C, McEachin R C, Stringham H M, Trager E, White P P, Balow J, Birznieks G, Chang J, Eldridge W
Abstract excerpt
Type 2 diabetes mellitus is a complex disorder encompassing multiple metabolic defects. We report results from an autosomal genome scan for type 2 diabetes-related quantitative traits in 580 Finnish families ascertained for an affected sibling pair and analyzed by the variance components-based quantitative-trait locus (QTL) linkage approach. We analyzed diabetic and nondiabetic subjects separately, because of the...
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