Article
An association between type 1 diabetes and the interleukin-1 receptor type 1 gene. The DiMe Study Group. Childhood Diabetes in Finland.
Human immunology - 1 Nov 1996
Metcalfe K A, Hitman G A, Pociot F, Bergholdt R, Tuomilehto-Wolf E, Tuomilehto J, Viswanathan M, Ramachandran A, Nerup J
Abstract excerpt
The polygenic susceptibility to type 1 diabetes is well established and recent studies have demonstrated linkage of a further locus on chromosome 2q to disease. We have studied a polymorphism of the interleukin-1 receptor type 1 gene (IL1R1) on chromosome 2q in type 1 diabetic and control subject...
Topics
- Adolescent
- Alleles
- Child
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- Female
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans
- Male
- Receptors, Interleukin-1