DQA1 and DQB1 heterodimers in insulin-dependent diabetes mellitus: a genetic-epidemiological study in Finland. DiMe Study Group.

doi:10.3109/07853899209167007

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Article

DQA1 and DQB1 heterodimers in insulin-dependent diabetes mellitus: a genetic-epidemiological study in Finland. DiMe Study Group.

Annals of medicine - 1 Dec 1992

Tuomilehto-Wolf E, Tuomilehto J, Hitman G A

Abstract excerpt

Susceptibility to insulin-dependent diabetes mellitus (IDDM) correlates with the absence of aspartic acid in position 57 of the DQB1 and/or the presence of arginine in position 52 of the DQA1. It has been postulated that transcomplementation between the DQ alpha and beta chains of the two haploty...

Topics

Adolescent
Alleles
Child
Diabetes Mellitus, Type 1
Disease Susceptibility
Female
Finland
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
Humans
Macromolecular Substances
Male

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