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Article

Mutants in position 69 of the Trp repressor of Escherichia coli K12 with altered DNA-binding specificity.

Molecular & general genetics : MGG - 12 Jun 1996

Günes C, Müller-Hill B

Abstract excerpt

Structural analysis by X-ray crystallography has indicated that direct contact occurs between Arg69, the second residue of the first helix of the helix-turnhelix (HTH) motif of the Trp repressor, and guanine in position 9 of the alpha-centred consensus trp operator. We therefore replaced residue 69 of the Trp repressor with Gly, Ile, Leu or Gln and tested the resultant repressor mutants for their binding to...

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Identifiers

PMID: 8676876
DOI: 10.1007/BF02172524

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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