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Article

Shared operator recognition specificity between Trp repressor and the repressors of bacteriophage 434.

Journal of molecular biology - 20 Feb 1991

Somerville R L, Bogosian G, Zeilstra-Ryalls J H

Abstract excerpt

Trp repressor is the only DNA-binding regulatory protein having a helix-turn-helix motif that has been reported to engage its operator target by a mechanism termed indirect readout: the Trp repressor-DNA interface is replete with hydrogen bonds between amino acid residues and non-esterified oxygen atoms of the sugar-phosphate backbone, and contains numerous specifically positioned water molecules. In Escherichia...

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Source

Identifiers

PMID: 2005612
DOI: 10.1016/0022-2836(91)90516-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Shared operator recognition specificity between Trp repressor and the repressors of bacteriophage 434.PMID 2005612Read ↗

Probing the physical basis for trp repressor-operator recognition.Semantic proximity Read ↗

Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences.Semantic proximity Read ↗

The three-dimensional structure of trp repressor.Semantic proximity Read ↗

The stereochemistry and biochemistry of the trp repressor-operator complex.Semantic proximity Read ↗

Directed evolution of a synthetic phylogeny of programmable Trp repressors.Semantic proximity Read ↗

Enhanced operator binding by trp superrepressors of Escherichia coli.Semantic proximity Read ↗

A negative electrostatic determinant mediates the association between the Escherichia coli trp repressor and its operator DNA.Semantic proximity Read ↗

Mutants in position 69 of the Trp repressor of Escherichia coli K12 with altered DNA-binding specificity.Semantic proximity Read ↗

An alkaline phosphatase protection assay to investigate trp repressor/operator interactions.Semantic proximity Read ↗

Temperature-sensitive mutations in the bacteriophage Mu c repressor locate a 63-amino-acid DNA-binding domain.Semantic proximity Read ↗

Indirect readout of DNA sequence by p22 repressor: roles of DNA and protein functional groups in modulating DNA conformation.Semantic proximity Read ↗

Differential recognition of OR1 and OR3 by bacteriophage 434 repressor and Cro.Semantic proximity Read ↗

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