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Article

Mutant tryptophan aporepressors with altered specificities of corepressor recognition.

Genetics - 1 May 1991

Arvidson D N, Shapiro M, Youderian P

Abstract excerpt

The Escherichia coli trpR gene encodes tryptophan aporepressor, which binds the corepressor ligand, L-tryptophan, to form an active repressor complex. The side chain of residue valine 58 of Trp aporepressor sits at the bottom of the corepressor (L-tryptophan) binding pocket. Mutant trpR genes encoding changes of Val58 to the other 19 naturally occurring amino acids were made. Each of the mutant proteins requires...

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Identifiers

PMID: 2060777
DOI: 10.1093/genetics/128.1.29
PMCID: PMC1204450

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