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Cellular Targets of HIV-1 Protease: Just the Tip of the Iceberg?

9 Mar 2023

Abstract excerpt

Human immunodeficiency virus 1 (HIV-1) viral protease (PR) is one of the most studied viral enzymes and a crucial antiviral target. Despite its well-characterized role in virion maturation, an increasing body of research is starting to focus on its ability to cleave host cell proteins. Such findings are apparently in contrast with the dogma of HIV-1 PR activity being restricted to the interior of nascent virions...

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PMID: 36992421
DOI: 10.3390/v15030712

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