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Article

The C-terminal 25 amino acids of the protease and its substrate ICP35 of herpes simplex virus type 1 are involved in the formation of sealed capsids.

Journal of virology - 1 Jul 1995

Matusick-Kumar L, Newcomb W W, Brown J C, McCann P J, Hurlburt W, Weinheimer S P, Gao M

Abstract excerpt

The herpes simplex virus type 1 protease and its substrate, ICP35, are involved in the assembly of viral capsids. Both proteins are encoded by a single open reading frame from overlapping mRNAs. The protease is autoproteolytically processed at two sites. The protease cleaves itself at the C-terminal site (maturation site) and also cleaves ICP35 at an identical site, releasing a 25-amino-acid (aa) peptide from...

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Identifiers

PMID: 7769696
DOI: 10.1128/JVI.69.7.4347-4356.1995
PMCID: PMC189175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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