Article
The C-terminal 25 amino acids of the protease and its substrate ICP35 of herpes simplex virus type 1 are involved in the formation of sealed capsids.
Journal of virology - 1 Jul 1995
Matusick-Kumar L, Newcomb W W, Brown J C, McCann P J, Hurlburt W, Weinheimer S P, Gao M
Abstract excerpt
The herpes simplex virus type 1 protease and its substrate, ICP35, are involved in the assembly of viral capsids. Both proteins are encoded by a single open reading frame from overlapping mRNAs. The protease is autoproteolytically processed at two sites. The protease cleaves itself at the C-termi...
Topics
- Animals
- Base Sequence
- Capsid
- Chlorocebus aethiops
- Microscopy, Electron
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Serine Endopeptidases
- Vero Cells
- Viral Proteins