A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells.

doi:10.1128/jvi.74.24.11608-11618.2000

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Article

A null mutation in the UL36 gene of herpes simplex virus type 1 results in accumulation of unenveloped DNA-filled capsids in the cytoplasm of infected cells.

Journal of virology - 1 Dec 2000

Desai P J

Abstract excerpt

The UL36 open reading frame (ORF) encodes the largest herpes simplex virus type 1 (HSV-1) protein, a 270-kDa polypeptide designated VP1/2, which is also a component of the virion tegument. A null mutation was generated in the UL36 gene to elucidate its role in the virus life cycle. Since the UL36 gene specifies an essential function, complementing cell lines transformed for sequences encoding the UL36 ORF were...

Topics

Capsid
Cell Line
DNA, Viral
Gene Expression Regulation, Viral
Genes, Viral
Herpes Simplex
Herpesvirus 1, Human
Humans
Mutation
Viral Proteins
Virion
Virus Assembly
Virus Replication

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Identifiers

PMID: 11090159
DOI: 10.1128/jvi.74.24.11608-11618.2000
PMCID: PMC112442

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