Article
Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids.
Journal of virology - 1 Aug 2000
Sheaffer A K, Newcomb W W, Brown J C, Gao M, Weller S K, Tenney D J
Abstract excerpt
Herpes simplex virus type 1 (HSV-1) capsids are initially assembled with an internal protein scaffold. The scaffold proteins, encoded by overlapping in-frame UL26 and UL26.5 transcripts, are essential for formation and efficient maturation of capsids. UL26 encodes an N-terminal protease domain, and its C-terminal oligomerization and capsid protein-binding domains are identical to those of UL26.5. The UL26...
Topics
- Blotting, Western
- Capsid
- Cell Line
- Electrophoresis, Polyacrylamide Gel
- Gene Expression Regulation, Viral
- Herpesvirus 1, Human
- Microscopy, Electron
- Mutation
- Serine Endopeptidases
- Transfection
- Viral Proteins
- Virus Assembly