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Article

Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids.

Journal of virology - 1 Aug 2000

Sheaffer A K, Newcomb W W, Brown J C, Gao M, Weller S K, Tenney D J

Abstract excerpt

Herpes simplex virus type 1 (HSV-1) capsids are initially assembled with an internal protein scaffold. The scaffold proteins, encoded by overlapping in-frame UL26 and UL26.5 transcripts, are essential for formation and efficient maturation of capsids. UL26 encodes an N-terminal protease domain, and its C-terminal oligomerization and capsid protein-binding domains are identical to those of UL26.5. The UL26...

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Source

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Identifiers

PMID: 10888623
DOI: 10.1128/jvi.74.15.6838-6848.2000
PMCID: PMC112201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids.PMID 10888623Read ↗

The 25 amino acid residues at the carboxy terminus of the herpes simplex virus type 1 UL26.5 protein are required for the formation of the capsid shell around the scaffold.Semantic proximity Read ↗

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