Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptides

16 Nov 2005

Abstract excerpt

Breast cancer remains the cancer with the highest mortality among women in the United States. Peptides derived from the oncogenic Tac1 gene (full transcript: betaPPT-A) stimulate the proliferation of breast cancer cells (BCCs) via seven-transmembrane G protein-coupled neurokinin 1 (NK1) and NK2 receptors. The NK1 gene could generate full-length (NK1-FL) and truncated (NK1-Tr) transcripts. NK1-Tr lacks 100...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Neuropeptides and Animal Physiology
Share to Proteoglycans and glycosaminoglycans research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16291810
DOI: 10.1073/pnas.0506351102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transformation of breast cells by truncated neurokinin-1 receptor is secondary to activation by preprotachykinin-A peptidesPMID 16291810Read ↗

Stromal-derived factor-1alpha induces a non-canonical pathway to activate the endocrine-linked Tac1 gene in non-tumorigenic breast cells.Semantic proximity Read ↗

New insight into the role of substance P/neurokinin‐1 receptor system in breast cancer progression and its crosstalk with microRNAsSemantic proximity Read ↗

Substance P Autocrine Signaling Contributes to Persistent HER2 Activation That Drives Malignant Progression and Drug Resistance in Breast CancerSemantic proximity Read ↗

Expression of Neurotensin and NT1 Receptor in Human Breast Cancer: A Potential Role in Tumor ProgressionSemantic proximity Read ↗

Facilitating Role of Preprotachykinin-I Gene in the Integration of Breast Cancer Cells within the Stromal Compartment of the Bone MarrowSemantic proximity Read ↗

Expression of neurotensin receptor-1 (NTS1) in primary breast tumors, cellular distribution, and association with clinical and biological factorsSemantic proximity Read ↗

Gene polymorphisms of TACR1 serve as the potential pharmacogenetic predictors of response to the neurokinin-1 receptor antagonist-based antiemetic regimens: a candidate-gene association study in breast cancer patients.Semantic proximity Read ↗

Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism.Semantic proximity Read ↗

Activation of trk-A but not trk-B signal transduction pathway inhibits growth of Neuroblastoma cellsSemantic proximity Read ↗

Nectin-4 cis-interacts with ErbB2 and its trastuzumab-resistant splice variants, enhancing their activation and DNA synthesisSemantic proximity Read ↗

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12Semantic proximity Read ↗

β-endorphin primes Natural Killer cells and NK-derived Extracellular Vesicle to enhance anti-tumor cytotoxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.