Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.

doi:10.1083/jcb.116.4.863

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Article

Deletion of the regulatory domain of protein kinase C alpha exposes regions in the hinge and catalytic domains that mediate nuclear targeting.

The Journal of cell biology - 1 Feb 1992

James G, Olson E

Abstract excerpt

Members of the protein kinase C (PKC) family are characterized by an NH2-terminal regulatory domain containing binding sites for calcium, phosphatidylserine, and diacylglycerol (or tumor-promoting phorbol esters), a small central hinge region and a COOH-terminal catalytic domain. We have construc...

Topics

Animals
Binding Sites
Cell Line
Enzyme Activation
Mutation
Myristic Acid
Myristic Acids
Nuclear Envelope
Phorbol 12,13-Dibutyrate
Protein Conformation
Protein Kinase C
Recombinant Fusion Proteins

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