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Article

Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation.

British journal of pharmacology - 1 Nov 1999

Al-Ani B, Saifeddine M, Kawabata A, Hollenberg M D

Abstract excerpt

1. Rat proteinase-activated receptor-2 (PAR2) variants were stably expressed in rat KNRK cells: (a) wild-type (wt) - PAR2; (b) PAR2PRR, with the extracellular loop 2 (EL-2) sequence P231E232E233mutated to PRR and (c) PAR2NET, with the EL-2 sequence, PEEV changed to NETL. Cell lines were evaluated for their sensitivity (calcium signalling) towards trypsin and the receptor-activating peptides, SLIGRL-NH2,...

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Identifiers

PMID: 10556949
DOI: 10.1038/sj.bjp.0702834
PMCID: PMC1571714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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