Article
C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. Role of receptor phosphorylation in signal attenuation.
The Journal of biological chemistry - 14 Apr 1995
Alblas J, van Etten I, Khanum A, Moolenaar W H
Abstract excerpt
The G protein-linked receptor for neurokinin A (NKA) couples to stimulation of phospholipase C and, in some cells, adenylyl cyclase. We have examined the function of the C-terminal cytoplasmic domain in receptor signaling and desensitization. We constructed C-terminal deletion mutants of the huma...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Cell Line
- Cyclic AMP
- Humans
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Kinase C
- Rats
- Receptors, Neurokinin-2
- Signal Transduction
- Spodoptera