Article
A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization.
Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 1997
Li H, Leeman S E, Slack B E, Hauser G, Saltsman W S, Krause J E, Blusztajn J K, Boyd N D
Abstract excerpt
Two isoforms of the substance P (SP) receptor, differing in the length of the cytoplasmic carboxyl-terminus by approximately 8 kDa, have been detected previously in rat salivary glands and other tissues. The binding and functional properties of these two isoforms have been investigated using full-length (407 amino acids) and carboxyl-terminally truncated (324 amino acids) rat SP receptors transfected stably into...
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