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Article

Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer.

Journal of the National Cancer Institute - 15 Dec 1993

Mitsudomi T, Oyama T, Kusano T, Osaki T, Nakanishi R, Shirakusa T

Abstract excerpt

BACKGROUND: Inactivation of the p53 tumor suppressor gene (also known as TP53) through a point mutation and/or loss of heterozygosity is one of the most common genetic changes found in various types of human tumors. PURPOSE: Our purpose was to investigate the relationship between the presence of p53 gene mutations and survival of patients with non-small-cell lung cancer (NSCLC) of all stages who underwent surgery...

Topics

Aged
Analysis of Variance
Carcinoma, Non-Small-Cell Lung
Exons
Female
Genes, p53
Humans
Lung Neoplasms
Male
Mutation
Point Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Predictive Value of Tests

Prognosis

Proportional Hazards Models

Survival Analysis

Source

Identifiers

PMID: 8246288
DOI: 10.1093/jnci/85.24.2018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8246288-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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