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Article

TP53 mutations and lung cancer: not all mutations are created equal.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2014

Govindan Ramaswamy, Weber Jason

Abstract excerpt

Mutations in TP53 are common in non-small cell lung cancer. Apart from the loss of tumor-suppressor functions, TP53 mutations may result in gain of function favoring cellular proliferation, inhibition of apoptosis, and genomic instability. Some TP53 mutations are more likely to affect the course of the disease than others.

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Identifiers

PMID: 24916693
DOI: 10.1158/1078-0432.CCR-14-0899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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