Inducing the loss of immunoglobulin lambda light chain production and the rearrangement of a previously excluded allele in human plasma B cell lines with concanavalin A.

doi:10.1074/jbc.271.29.17404

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Article

Inducing the loss of immunoglobulin lambda light chain production and the rearrangement of a previously excluded allele in human plasma B cell lines with concanavalin A.

The Journal of biological chemistry - 19 Jul 1996

Tachibana H, Ushio Y, Krungkasem C, Shirahata S

Abstract excerpt

We investigated the expression of differential lambda light chains in human B cell lines secreting immunoglobulin (Ig). When these cell lines were cultured with concanavalin A for a long period of time, a subpopulation of some but not all of these cell lines was induced to express new lambda ligh...

Topics

Adenocarcinoma
Alleles
B-Lymphocytes
Base Sequence
Burkitt Lymphoma
Cell Line
Concanavalin A
DNA Primers
DNA-Binding Proteins
Flow Cytometry
Gene Rearrangement
Genes, Immunoglobulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homeodomain Proteins

Humans

Hybridomas

Immunoglobulin lambda-Chains

Lung Neoplasms

Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8663345
DOI: 10.1074/jbc.271.29.17404

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8663345-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Inducing the loss of immunoglobulin lambda light chain production and the rearrangement of a previously excluded allele in human plasma B cell lines with concanavalin A.PMID 8663345Read ↗

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