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Article

Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement.

Blood - 1 Jan 1999

Tachibana H, Haruta H, Yamada K

Abstract excerpt

We identified an antibody-secreting human B-cell line (HTD8), which actively replaces the production of the original lambda light chain with a new lambda chain (light chain shifting) at a high rate. Loss of the original rearranged lambda light chain occurs by significantly reducing the amount of transcript expressed. Expression of the new lambda chain, which replaces the original lambda chain, occurs by...

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PMID: 9864162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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