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Article

Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement.

Blood - 1 Jan 1999

Tachibana H, Haruta H, Yamada K

Abstract excerpt

We identified an antibody-secreting human B-cell line (HTD8), which actively replaces the production of the original lambda light chain with a new lambda chain (light chain shifting) at a high rate. Loss of the original rearranged lambda light chain occurs by significantly reducing the amount of...

Topics

Alleles
B-Lymphocytes
Base Sequence
Cell Line
Cell Separation
Clone Cells
Gene Expression Regulation
Gene Rearrangement, B-Lymphocyte, Light Chain
Humans
Immunoglobulin Variable Region
Immunoglobulin lambda-Chains
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasma Cells

Receptors, Antigen, B-Cell

Source

Identifiers

PMID: 9864162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9864162-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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