Article
Up-regulated recombination-activating gene expression in sIg- variants of a human mature B cell line undergoing secondary Ig lambda rearrangements in cell culture.
European journal of immunology - 1 Jul 1993
Stiernholm N B, Berinstein N L
Abstract excerpt
To study the role of surface immunoglobulin (sIg) expression in the control of rearrangement activity at the Ig light chain loci, we established rare sIg- clones (lambda-) from a human sIg+ B cell line (mu lambda+). Upon expansion of these sIg- clones, surface immunofluorescence analysis revealed...
Topics
- Alleles
- B-Lymphocytes
- DNA-Binding Proteins
- Gene Rearrangement, B-Lymphocyte, Light Chain
- Genes
- Homeodomain Proteins
- Humans
- Immunoglobulin lambda-Chains
- In Vitro Techniques
- Nuclear Proteins
- Proteins
- Receptors, Antigen, B-Cell
- Recombination, Genetic
- Tumor Cells, Cultured
- Up-Regulation