Article
Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.
Immunity - 1 Jun 1999
Iritani B M, Alberola-Ila J, Forbush K A, Perimutter R M
Abstract excerpt
Successful in-frame rearrangement of immunoglobulin heavy chain genes or T cell antigen receptor (TCR) beta chain genes in lymphocyte progenitors results in formation of pre-BCR and pre-TCR complexes. These complexes signal progenitor cells to mature, expand in cell number, and suppress further rearrangements at the immunoglobulin heavy chain or TCRbeta chain loci, thereby ensuring allelic exclusion. We used...
Topics
- Alkyl and Aryl Transferases
- Alleles
- Cell Differentiation
- DNA-Binding Proteins
- Enzyme Activation
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
- Lymphocyte Subsets
- Mitogen-Activated Protein Kinase Kinases
- Protein Kinases
- Proto-Oncogene Proteins c-raf
- Recombinant Fusion Proteins
- Signal Transduction