Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.

Immunity - 1 Jun 1999

Iritani B M, Alberola-Ila J, Forbush K A, Perimutter R M

Abstract excerpt

Successful in-frame rearrangement of immunoglobulin heavy chain genes or T cell antigen receptor (TCR) beta chain genes in lymphocyte progenitors results in formation of pre-BCR and pre-TCR complexes. These complexes signal progenitor cells to mature, expand in cell number, and suppress further rearrangements at the immunoglobulin heavy chain or TCRbeta chain loci, thereby ensuring allelic exclusion. We used...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkyl and Aryl Transferases
Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Lymphocyte Subsets

Share to Mitogen-Activated Protein Kinase Kinases

Share to Protein Kinases

Share to Proto-Oncogene Proteins c-raf

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 10403646
DOI: 10.1016/s1074-7613(00)80070-9
PMCID: PMC5310940

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors.PMID 10403646Read ↗

Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion.Semantic proximity Read ↗

Regulation of TCR alpha and beta gene allelic exclusion during T-cell development.Semantic proximity Read ↗

Allelic exclusion and differentiation by protein kinase C-mediated signals in immature thymocytes.Semantic proximity Read ↗

A role for MAPK in feedback inhibition of Tcrb recombination.Semantic proximity Read ↗

Long-Range Control of V(D)J Recombination & Allelic Exclusion: Modeling Views.Semantic proximity Read ↗

The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.Semantic proximity Read ↗

Allelic exclusion in B and T lymphopoiesis.Semantic proximity Read ↗

Branching out to gain control: how the pre-TCR is linked to multiple functions.Semantic proximity Read ↗

The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression.Semantic proximity Read ↗

Pleiotropic changes controlled by the pre-T-cell receptor.Semantic proximity Read ↗

Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.Semantic proximity Read ↗

Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.