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Article

Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice.

The European journal of neuroscience - 1 Jan 2003

Berrendero Fernando, Castañé Anna, Ledent Catherine, Parmentier Marc, Maldonado Rafael, Valverde Olga

Abstract excerpt

CB1 cannabinoid and A2a adenosine receptors are highly expressed in the central nervous system where they modulate numerous physiological processes including emotional behaviour and the responses of several drugs of abuse. To investigate the contribution of these receptors in emotional-like responses and opioid dependence we have generated CB1/A2a double deficient mice (CB1-/-/A2a-/-). The spontaneous locomotor...

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Identifiers

PMID: 12542668
DOI: 10.1046/j.1460-9568.2003.02439.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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