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Article

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 2002

Newton Samuel S, Thome Johannes, Wallace Tanya L, Shirayama Yukihikko, Schlesinger Lee, Sakai Norio, Chen Jingshan, Neve Rachael, Nestler Eric J, Duman Ronald S

Abstract excerpt

The cAMP response element-binding protein (CREB) is a critical integrator of neural plasticity that is responsive in a brain region-specific manner to a variety of environmental and pharmacological stimuli, including widely prescribed antidepressant medications. We developed inducible transgenic...

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Identifiers

PMID: 12486182
PMCID: PMC6758459

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12486182-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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