Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].

doi:10.1126/science.7754373

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Article

Role of the chaperone protein Hsp104 in propagation of the yeast prion-like factor [psi+].

Science (New York, N.Y.) - 12 May 1995

Chernoff Y O, Lindquist S L, Ono B, Inge-Vechtomov S G, Liebman S W

Abstract excerpt

The yeast non-Mendelian factor [psi+] has been suggested to be a self-modified protein analogous to mammalian prions. Here it is reported that an intermediate amount of the chaperone protein Hsp104 was required for the propagation of the [psi+] factor. Over-production or inactivation of Hsp104 ca...

Topics

Fungal Proteins
Gene Expression
Heat-Shock Proteins
Mutation
Prions
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Suppression, Genetic

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