Article
[Modification of [PSI+] prion properties by the combination of amino acid changes within Sup35 protein N-domain].
Molekuliarnaia biologiia - 1 Jan 2000
Bondarev S A, Shirokolobova E D, Trubitsyna N P, Zhuravleva G A
Abstract excerpt
[PSI+] prion is an amyloid isoform of a release factor Sup35p (eRF3). The structure of these protein aggregates remains unclear despite a long term history of prion amyloids investigations. The N-terminal domain of Sup35p (which is responsible for a propagation of prion) shapes superpleated beta-structure, according to modern concepts. Recently we constructed five double mutations within SUP35 sequence encoding...
Topics
- Alleles
- Amyloidogenic Proteins
- Gene Expression Regulation, Fungal
- Molecular Chaperones
- Mutation
- Peptide Termination Factors
- Protein Aggregates
- Protein Isoforms
- Protein Stability
- Protein Structure, Secondary