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[Modification of [PSI+] prion properties by the combination of amino acid changes within Sup35 protein N-domain].

Molekuliarnaia biologiia - 1 Jan 2000

Bondarev S A, Shirokolobova E D, Trubitsyna N P, Zhuravleva G A

Abstract excerpt

[PSI+] prion is an amyloid isoform of a release factor Sup35p (eRF3). The structure of these protein aggregates remains unclear despite a long term history of prion amyloids investigations. The N-terminal domain of Sup35p (which is responsible for a propagation of prion) shapes superpleated beta-structure, according to modern concepts. Recently we constructed five double mutations within SUP35 sequence encoding...

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PMID: 25850301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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