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Article

Murine lupus susceptibility locus Sle1a requires the expression of two sub-loci to induce inflammatory T cells.

Genes and immunity - 1 Oct 2010

Cuda C M, Zeumer L, Sobel E S, Croker B P, Morel L

Abstract excerpt

The NZM2410-derived Sle1a lupus susceptibility locus induces activated autoreactive CD4(+) T cells and reduces the number and function of Foxp3(+) regulatory T cells (Tregs). In this study, we first showed that Sle1a contributes to autoimmunity by increasing antinuclear antibody production when expressed on either NZB or NZW heterozygous genomes, and by enhancing the chronic graft versus host disease response...

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Identifiers

PMID: 20445563
DOI: 10.1038/gene.2010.23
PMCID: PMC2958247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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