Article
The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.
Nucleic acids research - 15 May 1996
Gallie D R, Lewis N J, Marzluff W F
Abstract excerpt
The metazoan cell cycle-regulated histone mRNAs are the only known cellular mRNAs that do not terminate in a poly(A) tall. Instead, mammalian histone mRNAs terminate in a highly conserved stem-loop structure which is required for 3'-end processing and regulates mRNA stability. The poly(A) tail no...
Topics
- Animals
- Base Sequence
- CHO Cells
- Cricetinae
- Drug Stability
- Gene Expression Regulation
- Genes, Reporter
- Histones
- Luciferases
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Poly A
- Protein Biosynthesis
- RNA, Messenger
- Reticulocytes
- Structure-Activity Relationship
- Transfection