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Article

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.

PloS one - 4 Dec 2009

Salzler Harmony R, Davidson Jean M, Montgomery Nathan D, Duronio Robert J

Abstract excerpt

BACKGROUND: Metazoan replication-dependent histone mRNAs terminate in a conserved stem-loop structure rather than a polyA tail. Formation of this unique mRNA 3' end requires Stem-loop Binding Protein (SLBP), which directly binds histone pre-mRNA and stimulates 3' end processing. The 3' end stem-loop is necessary for all aspects of histone mRNA metabolism, including replication coupling, but its importance to...

Topics

Animals
Cell Proliferation
Chromosomal Position Effects
DNA Breaks, Double-Stranded
Drosophila Proteins
Drosophila melanogaster
Euchromatin
Genetic Markers
Genomic Instability
Heterochromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histones

Loss of Heterozygosity

Mitosis

Mutation

Polyploidy

RNA Precursors

RNA Processing, Post-Transcriptional

RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19997601
DOI: 10.1371/journal.pone.0008168
PMCID: PMC2781718

Genes

SLBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.PMID 19997601Read ↗

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Semantic proximity Read ↗

Drosophila stem-loop binding protein intracellular localization is mediated by phosphorylation and is required for cell cycle-regulated histone mRNA expression.Semantic proximity Read ↗

U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.Semantic proximity Read ↗

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficitsSemantic proximity Read ↗

Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.Semantic proximity Read ↗

Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.Semantic proximity Read ↗

Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.Semantic proximity Read ↗

Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.Semantic proximity Read ↗

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.Semantic proximity Read ↗

The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.Semantic proximity Read ↗

Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs.Semantic proximity Read ↗

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