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Article

Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.

Nucleic acids research - 11 Nov 1994

Williams A S, Ingledue T C, Kay B K, Marzluff W F

Abstract excerpt

The stem-loop structure at the 3' end of replication-dependent histone mRNA is required for efficient pre-mRNA processing, localization of histone mRNA to the polyribosomes, and regulation of histone mRNA degradation. A protein, the stem-loop binding protein (SLBP), binds the 3' end of histone mRNA and is thought to mediate some or all of these processes. A mutant histone mRNA with two nucleotide changes in the...

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Identifiers

PMID: 7984415
DOI: 10.1093/nar/22.22.4660
PMCID: PMC308515

Genes

SLBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.PMID 7984415Read ↗

Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

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Structure of the histone mRNA hairpin required for cell cycle regulation of histone gene expression.Semantic proximity Read ↗

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.Semantic proximity Read ↗

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Semantic proximity Read ↗

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.Semantic proximity Read ↗

The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.Semantic proximity Read ↗

Molecular modeling to predict the structural and biological effects of mutations in a highly conserved histone mRNA loop sequence.Semantic proximity Read ↗

3' end mRNA processing: molecular mechanisms and implications for health and disease.Semantic proximity Read ↗

U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.Semantic proximity Read ↗

The N-terminal domains of FLASH and Lsm11 form a 2:1 heterotrimer for histone pre-mRNA 3'-end processing.Semantic proximity Read ↗

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