Article
Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.
Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2013
Moqtaderi Zarmik, Geisberg Joseph V, Jin Yi, Fan Xiaochun, Struhl Kevin
Abstract excerpt
Most eukaryotic genes express mRNAs with alternative polyadenylation sites at their 3' ends. Here we show that polyadenylated 3' termini in three yeast species (Saccharomyces cerevisiae, Kluyveromyces lactis, and Debaryomyces hansenii) are remarkably heterogeneous. Instead of a few discrete 3' ends, the average yeast gene has an "end zone," a >200 bp window with >60 distinct poly(A) sites, the most used of which...
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