Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.

Genes & development - 15 Jan 2001

Sullivan E, Santiago C, Parker E D, Dominski Z, Yang X, Lanzotti D J, Ingledue T C, Marzluff W F, Duronio R J

Abstract excerpt

Replication-associated histone genes encode the only metazoan mRNAs that lack polyA tails, ending instead in a conserved 26-nt sequence that forms a stem-loop. Most of the regulation of mammalian histone mRNA is posttranscriptional and mediated by this unique 3' end. Stem-loop-binding protein (SLBP) binds to the histone mRNA 3' end and is thought to participate in all aspects of histone mRNA metabolism, including...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Insect
Share to Histones

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insect Proteins

Share to mRNA Cleavage and Polyadenylation Factors

Share to Oocytes

Share to RNA Processing, Post-Transcriptional

Share to Xenopus

Share to Xenopus Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 11157774
DOI: 10.1101/gad.862801
PMCID: PMC312608

Genes

SLBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.PMID 11157774Read ↗

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

Drosophila stem-loop binding protein intracellular localization is mediated by phosphorylation and is required for cell cycle-regulated histone mRNA expression.Semantic proximity Read ↗

Phosphorylation of stem-loop binding protein (SLBP) on two threonines triggers degradation of SLBP, the sole cell cycle-regulated factor required for regulation of histone mRNA processing, at the end of S phase.Semantic proximity Read ↗

Changes in the stem-loop at the 3' terminus of histone mRNA affects its nucleocytoplasmic transport and cytoplasmic regulation.Semantic proximity Read ↗

U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.Semantic proximity Read ↗

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.Semantic proximity Read ↗

Abrogation of Stem Loop Binding Protein (Slbp) function leads to a failure of cells to transition from proliferation to differentiation, retinal coloboma and midline axon guidance deficitsSemantic proximity Read ↗

Stem–loop binding protein expressed in growing oocytes is required for accumulation of mRNAs encoding histones H3 and H4 and for early embryonic development in the mouseSemantic proximity Read ↗

Biochemical Fractionation of Time-Resolved Drosophila Embryos Reveals Similar Transcriptomic Alterations in Replication Checkpoint and Histone mRNA Processing Mutants.Semantic proximity Read ↗

Mutations in the RNA binding domain of stem-loop binding protein define separable requirements for RNA binding and for histone pre-mRNA processing.Semantic proximity Read ↗

Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

Cell-cycle-dependent repression of histone gene transcription by histone H4Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.