Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other Tumors

15 Dec 2004

Abstract excerpt

Mutations of the human type Ialpha regulatory subunit (RIalpha) of cyclic AMP-dependent protein kinase (PKA; PRKAR1A) lead to altered kinase activity, primary pigmented nodular adrenocortical disease, and tumors of the thyroid and other tissues. To bypass the early embryonic lethality of Prkar1a(-/-) mice, we established transgenic mice carrying an antisense transgene for Prkar1a exon 2 (X2AS) under the control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac tumors and thrombi
Share to Neuroblastoma Research and Treatments
Share to Vascular Tumors and Angiosarcomas

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15604237
DOI: 10.1158/0008-5472.can-04-3620

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Down-Regulation of Regulatory Subunit Type 1A of Protein Kinase A Leads to Endocrine and Other TumorsPMID 15604237Read ↗

A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.Semantic proximity Read ↗

PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.Semantic proximity Read ↗

Hematopoietic neoplasms in Prkar2a-deficient mice.Semantic proximity Read ↗

Minireview: PRKAR1A: Normal and Abnormal FunctionsSemantic proximity Read ↗

A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues.Semantic proximity Read ↗

Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency.Semantic proximity Read ↗

Mouse Prkar1a haploinsufficiency leads to an increase in tumors in the Trp53+/− or Rb1+/− backgrounds and chemically induced skin papillomas by dysregulation of the cell cycle and Wnt signalingSemantic proximity Read ↗

Protein kinase A alterations in endocrine tumors.Semantic proximity Read ↗

PRKAR1A and Thyroid TumorsSemantic proximity Read ↗

Use of mouse models to understand the molecular basis of tissue-specific tumorigenesis in the Carney complex.Semantic proximity Read ↗

Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.Semantic proximity Read ↗

Protein kinase A and its role in human neoplasia: the Carney complex paradigm.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.