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Article

Extracellular protein kinase A as a cancer biomarker: its expression by tumor cells and reversal by a myristate-lacking Calpha and RIIbeta subunit overexpression.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Cho Y S, Park Y G, Lee Y N, Kim M K, Bates S, Tan L, Cho-Chung Y S

Abstract excerpt

Overexpression of cAMP-dependent protein kinase (PKA) type I isozyme is associated with cell proliferation and neoplastic transformation. The presence of PKA on the external surface of LS-174T human colon carcinoma cells has been shown. Here, we show that cancer cells of various cell types excrete PKA into the conditioned medium. This extracellular PKA (ECPKA) is present in active, free catalytic subunit (C...

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Identifiers

PMID: 10639166
DOI: 10.1073/pnas.97.2.835
PMCID: PMC15417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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