Article
Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.
The EMBO journal - 3 Jun 1996
Ruiz-Echevarria M J, Peltz S W
Abstract excerpt
In the yeast Saccharomyces cerevisiae, premature translation termination promotes rapid degradation of mRNAs. Accelerated decay requires the presence of specific cis-acting sequences which have been defined as downstream elements. It has been proposed that the role of the downstream element may b...
Topics
- Base Sequence
- DNA Primers
- DNA-Binding Proteins
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Molecular Sequence Data
- Mutation
- Peptide Chain Termination, Translational
- Protein Biosynthesis
- Protein Kinases
- RNA, Fungal