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Article

Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.

The EMBO journal - 3 Jun 1996

Ruiz-Echevarria M J, Peltz S W

Abstract excerpt

In the yeast Saccharomyces cerevisiae, premature translation termination promotes rapid degradation of mRNAs. Accelerated decay requires the presence of specific cis-acting sequences which have been defined as downstream elements. It has been proposed that the role of the downstream element may be to promote translational reinitiation or ribosomal pausing. The GCN4 gene produces an mRNA that contains four short...

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Identifiers

PMID: 8654378
PMCID: PMC450218

Genes

PGK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.PMID 8654378Read ↗

Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.Semantic proximity Read ↗

mRNA destabilization triggered by premature translational termination depends on at least three cis-acting sequence elements and one trans-acting factor.Semantic proximity Read ↗

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.Semantic proximity Read ↗

cis-acting sequences involved in the translational control of GCN4 expression.Semantic proximity Read ↗

Premature translational termination triggers mRNA decapping.Semantic proximity Read ↗

Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.Semantic proximity Read ↗

The position of the target site for engineered nucleases improves the aberrant mRNA clearance in in vivo genome editing.Semantic proximity Read ↗

Analysis of Dom34 and its function in no-go decay.Semantic proximity Read ↗

Leaky termination at premature stop codons antagonizes nonsense-mediated mRNA decay in S. cerevisiae.Semantic proximity Read ↗

Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA.Semantic proximity Read ↗

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