Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Premature translational termination triggers mRNA decapping.

Nature - 18 Aug 1994

Muhlrad D, Parker R

Abstract excerpt

The degradation of messenger RNA in eukaryotic cells is initiated by endonucleolytic cleavage or by shortening of the poly(A) tail, which for some mRNAs activates a deadenylation-dependent decapping reaction. One type of rapid mRNA degradation in eukaryotes is caused by premature termination of translation. This turnover process prevents the translation of aberrant mRNAs, may affect the abundance and splicing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Codon
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Peptide Chain Termination, Translational

Share to Phosphoglycerate Kinase

Share to Saccharomyces cerevisiae

Share to Transcription, Genetic

Source

Identifiers

PMID: 8052314
DOI: 10.1038/370578a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Premature translational termination triggers mRNA decapping.PMID 8052314Read ↗

Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae.Semantic proximity Read ↗

Rapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathway.Semantic proximity Read ↗

Recognition of yeast mRNAs as "nonsense containing" leads to both inhibition of mRNA translation and mRNA degradation: implications for the control of mRNA decapping.Semantic proximity Read ↗

mRNA quality control: an ancient machinery recognizes and degrades mRNAs with nonsense codons.Semantic proximity Read ↗

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function.Semantic proximity Read ↗

Exosome-mediated recognition and degradation of mRNAs lacking a termination codon.Semantic proximity Read ↗

The EDC4-XRN1 axis controls P-body dynamics to link mRNA decapping with decaySemantic proximity Read ↗

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

In plants, decapping prevents RDR6-dependent production of small interfering RNAs from endogenous mRNAs.Semantic proximity Read ↗

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.Semantic proximity Read ↗

Should we kill the messenger? The role of the surveillance complex in translation termination and mRNA turnover.Semantic proximity Read ↗

mRNA 3' tagging is induced by nonsense-mediated decay and promotes ribosome dissociation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.