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Article

Analysis of Dom34 and its function in no-go decay.

Molecular biology of the cell - 1 Jul 2009

Passos Dario O, Doma Meenakshi K, Shoemaker Christopher J, Muhlrad Denise, Green Rachel, Weissman Jonathan, Hollien Julie, Parker Roy

Abstract excerpt

Eukaryotic mRNAs are subject to quality control mechanisms that degrade defective mRNAs. In yeast, mRNAs with stalls in translation elongation are targeted for endonucleolytic cleavage by No-Go decay (NGD). The cleavage triggered by No-Go decay is dependent on Dom34p and Hbs1p, and Dom34 has been proposed to be the endonuclease responsible for mRNA cleavage. We created several Dom34 mutants and examined their...

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Identifiers

PMID: 19420139
DOI: 10.1091/mbc.e09-01-0028
PMCID: PMC2704154

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