Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA.

doi:10.1038/srep28234

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Article

Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA.

Scientific reports - 17 Jun 2016

Ikeuchi Ken, Inada Toshifumi

Abstract excerpt

Dom34-Hbs1 stimulates degradation of aberrant mRNAs lacking termination codons by dissociating ribosomes stalled at the 3' ends, and plays crucial roles in Nonstop Decay (NSD) and No-Go Decay (NGD). In the dom34Δ mutant, nonstop mRNA is degraded by sequential endonucleolytic cleavages induced by a stalled ribosome at the 3' end. Here, we report that ribosome-associated Asc1/RACK1 is required for the...

Topics

3' Untranslated Regions
Adaptor Proteins, Signal Transducing
Cell Cycle Proteins
Endoribonucleases
GTP-Binding Proteins
Mutation
RNA Stability
RNA, Fungal
RNA, Transfer, Amino Acyl
Ribosomes
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27312062
DOI: 10.1038/srep28234
PMCID: PMC4911565

Genes

RACK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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