Article
Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.
Molecular and cellular biology - 1 Feb 1995
Hagan K W, Ruiz-Echevarria M J, Quan Y, Peltz S W
Abstract excerpt
Several lines of evidence indicate that the processes of mRNA turnover and translation are intimately linked and that understanding this relationship is critical to elucidating the mechanism of mRNA decay. One clear example of this relationship is the observation that nonsense mutations can accel...
Topics
- Alleles
- Base Sequence
- Exodeoxyribonuclease V
- Exodeoxyribonucleases
- Genes, Fungal
- Histones
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Oligodeoxyribonucleotides
- Phosphoglycerate Kinase
- Plasmids
- Protein Biosynthesis
- RNA, Messenger
- Recombinant Proteins
- Saccharomyces cerevisiae
- Substrate Specificity
- Transcription, Genetic