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Article

Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.

Nucleic acids research - 11 Oct 1995

Grant C M, Miller P F, Hinnebusch A G

Abstract excerpt

Translation of yeast GCN4 mRNA occurs by a reinitiation mechanism that is modulated by amino acid levels in the cell. Ribosomes which translate the first of four upstream open reading frames (uORFs) in the mRNA leader resume scanning and can reinitiate downstream. Under non-starvation conditions reinitiation occurs at one of the remaining three uORFs and GCN4 is repressed. Under starvation conditions, in...

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Identifiers

PMID: 7479046
DOI: 10.1093/nar/23.19.3980
PMCID: PMC307320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.PMID 7479046Read ↗

The RNA recognition motif of eukaryotic translation initiation factor 3g (eIF3g) is required for resumption of scanning of posttermination ribosomes for reinitiation on GCN4 and together with eIF3i stimulates linear scanning.Semantic proximity Read ↗

Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.Semantic proximity Read ↗

The h subunit of eIF3 promotes reinitiation competence during translation of mRNAs harboring upstream open reading frames.Semantic proximity Read ↗

cis-acting sequences involved in the translational control of GCN4 expression.Semantic proximity Read ↗

The eukaryotic initiation factor (eIF) 4G HEAT domain promotes translation re-initiation in yeast both dependent on and independent of eIF4A mRNA helicase.Semantic proximity Read ↗

Termination and peptide release at the upstream open reading frame are required for downstream translation on synthetic shunt-competent mRNA leaders.Semantic proximity Read ↗

An <i>in vitro</i> assay of MCTS1-DENR-dependent re-initiation and ribosome profiling uncover the activity of MCTS2 and distinct function of eIF2DSemantic proximity Read ↗

Interplay between GCN2 and GCN4 expression, translation elongation factor 1 mutations and translational fidelity in yeast.Semantic proximity Read ↗

Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.Semantic proximity Read ↗

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.Semantic proximity Read ↗

Emerging links between initiation of translation and human diseases.Semantic proximity Read ↗

Transient idling of posttermination ribosomes ready to reinitiate protein synthesis.Semantic proximity Read ↗

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