Article
Sequences 5' of the first upstream open reading frame in GCN4 mRNA are required for efficient translational reinitiation.
Nucleic acids research - 11 Oct 1995
Grant C M, Miller P F, Hinnebusch A G
Abstract excerpt
Translation of yeast GCN4 mRNA occurs by a reinitiation mechanism that is modulated by amino acid levels in the cell. Ribosomes which translate the first of four upstream open reading frames (uORFs) in the mRNA leader resume scanning and can reinitiate downstream. Under non-starvation conditions...
Topics
- Alleles
- Codon
- DNA-Binding Proteins
- Deoxyribonuclease HindIII
- Escherichia coli
- Fungal Proteins
- Gene Deletion
- Gene Expression
- Gene Transfer Techniques
- Nucleic Acid Hybridization
- Open Reading Frames
- Plasmids
- Polymerase Chain Reaction
- Protein Biosynthesis
- Protein Kinases
- Protein Sorting Signals
- RNA Probes
- RNA, Messenger