Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

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Article

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

Cancer research - 1 Jun 1996

Prendergast G C, Davide J P, Lebowitz P F, Wechsler-Reya R, Kohl N E

Abstract excerpt

Pharmacological inhibitors of the housekeeping enzyme farnesyl transferase (FT) inhibit the growth of ras-transformed cells in vitro and in vivo without antiproliferative effects on normal cells. In one direction to analyze the basis for this selectivity and to study modes of drug resistance that arise in animals, we characterized a variant ras-transformed cell line, 749r-1, which was resistant to phenotypic...

Topics

Actins
Alkyl and Aryl Transferases
Animals
Cell Transformation, Neoplastic
Cytoskeleton
Drug Resistance
Enzyme Inhibitors
Farnesyltranstransferase
GTP-Binding Proteins
Genes, ras
Membrane Proteins
Myristates
Oligopeptides
Phenotype
Protein Processing, Post-Translational
Rats
Transferases
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8653708

Provenance

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