Article
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
PloS one - 1 Jan 2011
Weisberg Ellen, Ray Arghya, Nelson Erik, Adamia Sophia, Barrett Rosemary, Sattler Martin, Zhang Chengsheng, Daley John F, Frank David, Fox Edward, Griffin James D
Abstract excerpt
OBJECTIVES: Clinical responses achieved with FLT3 kinase inhibitors in acute myeloid leukemia (AML) are typically transient and partial. Thus, there is a need for identification of molecular mechanisms of clinical resistance to these drugs. In response, we characterized MOLM13 AML cell lines made...
Topics
- Cell Line, Tumor
- Cell Proliferation
- Drug Resistance, Neoplasm
- Enzyme Stability
- Gene Expression Regulation, Neoplastic
- Half-Life
- Humans
- Leukemia, Myeloid, Acute
- Mutation
- Phosphorylation
- Piperazines