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Article

Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.

PloS one - 1 Jan 2011

Weisberg Ellen, Ray Arghya, Nelson Erik, Adamia Sophia, Barrett Rosemary, Sattler Martin, Zhang Chengsheng, Daley John F, Frank David, Fox Edward, Griffin James D

Abstract excerpt

OBJECTIVES: Clinical responses achieved with FLT3 kinase inhibitors in acute myeloid leukemia (AML) are typically transient and partial. Thus, there is a need for identification of molecular mechanisms of clinical resistance to these drugs. In response, we characterized MOLM13 AML cell lines made resistant to two structurally-independent FLT3 inhibitors. METHODS: MOLM13 cells were made drug resistant via...

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Identifiers

PMID: 21980431
DOI: 10.1371/journal.pone.0025351
PMCID: PMC3182213

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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