Article
Farnesylated proteins as anticancer drug targets: from laboratory to the clinic.
Current medicinal chemistry. Anti-cancer agents - 1 Mar 2004
Russo Patrizia, Loprevite Maura, Cesario Alfredo, Ardizzoni Andrea
Abstract excerpt
The knowledge that Ras was readily prenylated by protein FTase and that the inhibition of this reaction has the ability to revert the transformed phenotype, provided the rationale for the development of FTIs as anticancer drugs. Studies have shown that farnesylation of Ras is the first, obligatory first step in a series of post-translational modifications leading to membrane association, which, in turn,...
Topics
- Alkyl and Aryl Transferases
- Animals
- Antineoplastic Agents
- Cell Line, Tumor
- Clinical Trials as Topic
- Farnesyltranstransferase
- Humans
- Mutation
- Neoplasms
- Protein Prenylation
- ras Proteins