Article
Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.
Biological & pharmaceutical bulletin - 1 Apr 1994
Kanbe T, Tsuchiya K S, Hori M, Ekimoto H, Takahashi Y, Takeuchi T
Abstract excerpt
Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical...
Topics
- 3T3 Cells
- Animals
- Antibiotics, Antineoplastic
- Cell Division
- Cell Line, Transformed
- Genes, ras
- Humans
- Mice
- Mice, Nude
- Neoplasms, Experimental
- Phenotype