Article
Increased susceptibility of ras-transformed cells to phenylacetate is associated with inhibition of p21ras isoprenylation and phenotypic reversion.
International journal of cancer - 27 Sept 1995
Shack S, Chen L C, Miller A C, Danesi R, Samid D
Abstract excerpt
Alterations in the expression of ras oncogenes are characteristic of a wide variety of human neoplasms. Accumulating evidence has linked elevated ras expression with disease progression and with failure of tumors to respond to conventional therapies, including radiotherapy and certain chemotherapies. These observations led us to investigate the response of ras-transformed cells to the differentiation-inducer...
Topics
- 3T3 Cells
- Animals
- Antimetabolites, Antineoplastic
- Cell Differentiation
- Cell Transformation, Neoplastic
- Genes, ras
- Growth Inhibitors
- Humans
- Mice
- Phenotype
- Phenylacetates