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Article

Establishment of a human non-small cell lung cancer cell line resistant to gefitinib.

International journal of cancer - 10 Aug 2005

Koizumi Fumiaki, Shimoyama Tatsu, Taguchi Fumiko, Saijo Nagahiro, Nishio Kazuto

Abstract excerpt

The epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor gefitinib (Iressa, ZD1839) has shown promising activity preclinically and clinically. Because comparative investigations of drug-resistant sublines with their parental cells are useful approaches to identifying the mechanism of...

Topics

Adaptor Proteins, Signal Transducing
Carcinoma, Non-Small-Cell Lung
Cell Line, Tumor
Drug Resistance, Neoplasm
GRB2 Adaptor Protein
Gefitinib
Genes, erbB-1
Humans
Intracellular Signaling Peptides and Proteins
Lung Neoplasms
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Quinazolines

Son of Sevenless Protein, Drosophila

Source

Identifiers

PMID: 15761868
DOI: 10.1002/ijc.20985

Genes

EGFR
GRB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-15761868-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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