Article
Translationally controlled tumor protein is a target of tumor reversion.
Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2004
Tuynder Marcel, Fiucci Giusy, Prieur Sylvie, Lespagnol Alexandra, Géant Anne, Beaucourt Séverine, Duflaut Dominique, Besse Stéphanie, Susini Laurent, Cavarelli Jean, Moras Dino, Amson Robert, Telerman Adam
Abstract excerpt
By analyzing the gene expression profile between tumor cells and revertant counterparts that have a suppressed malignant phenotype, we previously reported a significant down-regulation of translationally controlled tumor protein (TCTP) in the revertants. In the present study, we derived, by using the H1 parvovirus as a selective agent, revertants from three major solid cancers: colon, lung, and melanoma cell...
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