Article

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent manner

2002-12-01

Abstract excerpt

Nonstandard abbreviations used: human diploid fibroblast (HDF); 6-anilino-5,8-quinolinequinone (LY83583); LY83583 (LY); mouse embryo fibroblasts (MEFs); elongation factor 1α (ELF1α); soluble guanylate cyclase β3 (sGC-β3); quantitative real-time PCR (qPCR); crossing point (CP); propidium iodide (PI); sodium nitroprusside (SNP); senescence-associated β-galactosidase (SA-β-gal); bromodeoxyuridine (BrdU); soluble guan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8697ace3-824a-52d3-a176-c83502623882
DOI: 10.1172/jci0216588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Induction of the Cdk inhibitor p21 by LY83583 inhibits tumor cell proliferation in a p53-independent mannerDOI 10.1172/jci0216588Read

Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation.Semantic proximity Read

Mutation in p53 and de-regulation of p53-related gene expression in three human cell lines immortalized with 4-nitroquinoline 1-oxide or 60Co gamma rays.Semantic proximity Read

Hydroxychloroquine Protects Against Cyclophosphamide-Induced Premature ovarian failure by Reducing Granulosa Cell Senescence via Regulation of the mtDNA-cGAS Signaling PathwaySemantic proximity Read

The Cell Cycle as a Target for Cancer Therapy: Basic and Clinical Findings with the Small Molecule Inhibitors Flavopiridol and UCN-01Semantic proximity Read

The Role of Cell Cycle Regulators in Cell Survival—Dual Functions of Cyclin-Dependent Kinase 20 and p21Cip1/Waf1Semantic proximity Read

Cell-specific pattern of berberine pleiotropic effects on different human cell linesSemantic proximity Read

Regulation of p27Kip1 and p57Kip2 Functions by Natural PolyphenolsSemantic proximity Read

Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays.Semantic proximity Read

CDKN3 expression is negatively associated with pathological tumor stage and CDKN3 inhibition promotes cell survival in hepatocellular carcinomaSemantic proximity Read

Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cellsSemantic proximity Read

Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts.Semantic proximity Read

VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cellsSemantic proximity Read