Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence.

The Journal of biological chemistry - 9 Apr 2010

Whibley Catherine, Odell Adam F, Nedelko Tatiana, Balaburski Gregor, Murphy Maureen, Liu Zhipei, Stevens Louisa, Walker John H, Routledge Michael, Hollstein Monica

Abstract excerpt

Research on cell senescence and immortalization of murine embryonic fibroblasts (MEFs) has revealed important clues about genetic control of senescence in humans. To investigate senescence and genetic alterations in the p53 pathway that lead to senescence bypass in culture, we compared the behavior of MEFs from wild-type mice with MEFs from Hupki mice, which harbor a humanized p53 gene. We found that humanizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Comet Assay

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to DNA Damage

Share to Fibroblasts

Share to Genes, p53

Share to Oxygen

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 20118236
DOI: 10.1074/jbc.M109.064444
PMCID: PMC2857011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence.PMID 20118236Read ↗

How to become immortal: let MEFs count the waysSemantic proximity Read ↗

Modeling wild type and mutant p53 in telomerase-immortalized human cellsSemantic proximity Read ↗

Role of p14ARF in Replicative and Induced Senescence of Human FibroblastsSemantic proximity Read ↗

MEF immortalization to investigate the ins and outs of mutagenesis.Semantic proximity Read ↗

Bypass of Senescence After Disruption of p21 <sup> <i>CIP1/WAF1</i> </sup> Gene in Normal Diploid Human FibroblastsSemantic proximity Read ↗

Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC-1α.Semantic proximity Read ↗

An efficient method for immortalizing mouse embryonic fibroblastsSemantic proximity Read ↗

Induced Pluripotent Stem Cell-Derived Fibroblasts Efficiently Engage Senescence Pathways But Show Increased Sensitivity to Stress InducersSemantic proximity Read ↗

Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.Semantic proximity Read ↗

An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivoSemantic proximity Read ↗

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.Semantic proximity Read ↗

p53 loss of function: implications for the processes of immortalization and tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.