Article
p53 mutations in human immortalized epithelial cell lines.
Carcinogenesis - 1 May 1993
Lehman T A, Modali R, Boukamp P, Stanek J, Bennett W P, Welsh J A, Metcalf R A, Stampfer M R, Fusenig N, Rogan E M
Abstract excerpt
Although rodent cells have been immortalized following transfection with a mutant p53 gene, the role of p53 in the immortalization of human cells is unknown. Therefore, human epithelial cell lines were examined for p53 mutations in exons 4-9 which include the evolutionarily conserved regions. A spontaneously immortalized skin keratinocyte cell line, HaCat, and three ras-transfected clones, have a p53 mutational...
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