Article
Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.
Proceedings of the National Academy of Sciences of the United States of America - 20 Feb 1996
Liang H C, Li H, McKinnon R A, Duffy J J, Potter S S, Puga A, Nebert D W
Abstract excerpt
Cytochrome P450 1A2 (CYP1A2) is a predominantly hepatic enzyme known to be important in the metabolism of numerous foreign chemicals of pharmacologic, toxicologic, and carcinogenic significance. CYP1A2 substrates include aflatoxin B1, acetaminophen, and a variety of environmental arylamines. To define better the developmental and metabolic functions of this enzyme, we developed a CYP1A2-deficient mouse line by...
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